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Cigarette smoke condensate stimulates urokinase production through the generation of reactive oxygen species and activation of the mitogen activated protein kinase pathways in human gingival fibroblasts

✍ Scribed by R. Gonzalez; R. Arancibia; M. Cáceres; J. Martínez; P. C. Smith

Book ID: 111262121
Publisher: John Wiley and Sons
Year: 2009
Tongue: English
Weight: 258 KB
Volume: 44
Category: Article
ISSN: 0022-3484
DOI: 10.1111/j.1600-0765.2008.01114.x

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## Abstract Blood vessel injury results in limited oxygen tension and diffusion leading to hypoxia, increased anaerobic metabolism, and elevated production of acidic metabolites that cannot be easily removed due to the reduced blood flow. Therefore, an acidic extracellular pH occurs in the local mi