## Abstract The influence of age at DMBA administration on (1) susceptibility to mammary tumor development, (2) the proportion of tumors which are ovaryβdependent, and (3) the frequency of spontaneous tumor regression was examined in female Lewis rats between 25 and 200 days of age. Tumor developme
Chroramphenicol and dextramycin as inhibitors of mammary gland carcinogenesis induced by 7,12-dimethylbenz(a)anthracene
β Scribed by T. A. Bogush; I. A. Konopleva; L. M. Shabad
- Publisher
- Springer US
- Year
- 1979
- Tongue
- English
- Weight
- 324 KB
- Volume
- 88
- Category
- Article
- ISSN
- 0007-4888
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## Abstract The relationship between mammary cell proliferation during pregnancy and susceptibility to 7,12βdimethylβbenz(a)anthracene (DMBA) was examined. DMBA was administered intravenously to SpragueβDawley rats on the 5th, 10th or 15th day of pregnancy. [^3^H]thymidine labelling index (LI) of t
To identify and compare t h e genetic lesions associated with tumorigenesis in rats carrying the mammary carcinoma suppressor (MCS) 1 gene, we induced mammary carcinomas in Wistar Furth WF) x Copenhagen (Cop))F, rats by using either 7,12-dimethylbenz[a]anthracene (DMBA) or radiation. The tumors were