Clinical chronopharmacology of oral sust
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B. Lemmer; B. Scheidel; H. Blume; H. -J. Becker
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Article
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1991
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Springer
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English
β 471 KB
In 10 healthy male subjects the pharmacokinetics and haemodynamic effects of sustained-release isosorbide-5-mononitrate 60 mg (IS-5-MN) were studied after oral administration at two different times in the day (08.00 h and 20.00 h). Effects on blood pressure and heart rate after 3 min standing uprigh