Chronic treatment with haloperidol diminishes the phencyclidine-induced sensorimotor gating deficit in rats
✍ Scribed by Ma∏gorzata Pietraszek; Krystyna Ossowska
- Publisher
- Springer-Verlag
- Year
- 1998
- Tongue
- English
- Weight
- 253 KB
- Volume
- 357
- Category
- Article
- ISSN
- 0028-1298
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Several lines of evidence (binding studies, reduced responsiveness of brain adenylate cyclase to noradrenergic stimulation, electrophysiological data) indicate that chronic treatment with antidepressant drugs induces subsensitivity of central ]~-adrenergic receptors. We studied the effect of acute (
Apomorphine (AP)-elicited sterotypic behavior and striatal 3H-spiroperidol binding sites were studied in rats given 3 weeks of chronic treatment with one of the following neuroleptic drugs: zotepine (10 or 20 mg/kg/day IP); thioridazine (10 or 20 mg/kg/day IP); haloperidol (2 or 5 mg/kg/day IP). On