The effect of chronic treatment with antidepressant drugs on salbutamol-induced hypoactivity in rats

✍ Scribed by Edmund Przegalinski; Leokadia Baran; Joanna Siwanowicz

• Publisher: Springer
• Year: 1983
• Tongue: English
• Weight: 540 KB
• Volume: 80
• Category: Article
• ISSN: 0033-3158
• DOI: 10.1007/bf00432120

✦ Synopsis

Several lines of evidence (binding studies, reduced responsiveness of brain adenylate cyclase to noradrenergic stimulation, electrophysiological data) indicate that chronic treatment with antidepressant drugs induces subsensitivity of central ]~-adrenergic receptors. We studied the effect of acute (single dose) and chronic (14 days, twice daily) treatment with imipramine, desmethylimipramine, amitriptyline, fluvoxamine and citalopram (10mg/kg, orally) on salbutamolinduced suppression of exploratory activity in rats. This effect of salbutamol was antagonized by chronic, but not acute treatment with antidepressants. Chronic treatment with antidepressants as a rule did not significantly affect exploratory activity. Our results may be regarded as functional evidence at the behavioural level for the subsensitivity of/?-adrenergic receptors.