Chronic Obstructive Pulmonary Disease: A Systemic Inflammatory Disease

✍ Scribed by Hiroyuki Nakamura, Kazutetsu Aoshiba (eds.)

• Publisher: Springer Singapore
• Year: 2017
• Tongue: English
• Leaves: 351
• Series: Respiratory Disease Series: Diagnostic Tools and Disease Managements
• Edition: 1
• Category: Library

✦ Synopsis

This book considers chronic obstructive pulmonary disease (COPD) not as a simple inflammation of the lung but as a systemic inflammatory disease. Beginning with epidemiological studies, etiology, diagnosis and treatment, it elaborates further, illustrating some comorbidities and associations with other respiratory diseases. As such it provides numerous improved and more comprehensive treatment methods, including drug therapies as well as some non-drug therapies. There are also chapters describing the pathogenesis, genetic abnormalities and newly discovered pathogenetic mechanisms that are expected to be studied further in the future.

Edited and written by pioneering researchers, each chapter summarizes the latest trends, describes future prospects and explores the unresolved and critical questions. Chronic Obstructive Pulmonary Disease - A Systemic Inflammatory Disease is a valuable resource to beginning researchers, physicians engaged in clinical practice, supervisors, and basic researchers whose work includes COPD.

✦ Table of Contents

Front Matter....Pages i-xi
Front Matter....Pages 1-1
Definition of Chronic Obstructive Pulmonary Disease (COPD): Is the Latest GOLD Classification of Severity Still Valid?....Pages 3-16
Epidemiology of COPD: Why Is the Disease So Poorly Recognized?....Pages 17-28
Front Matter....Pages 29-29
Genetic Predisposition to COPD: Are There Any Relevant Genes Determining the Susceptibility to Smoking?....Pages 31-55
Pathogenesis of COPD (Persistence of Airway Inflammation): Why Does Airway Inflammation Persist After Cessation of Smoking?....Pages 57-72
Pathogenesis of COPD 3: Oxidative Stress – Is There a Possibility of Developing New Drugs from the Standpoint of This Pathogenetic Mechanism?....Pages 73-93
Pathogenesis of COPD 4 – Cell Death, Senescence, and Autophagy: Is There a Possibility of Developing New Drugs from the Standpoint of This Pathogenetic Mechanism?....Pages 95-111
Front Matter....Pages 113-113
Pathogenesis of Comorbidities in COPD: By What Mechanism Does Long-Term Smoking Cause Systemic Inflammation?....Pages 115-133
Assessment of Inflammation in COPD: Are There any Biomarkers that Can be Used to Assess Pulmonary and Systemic Inflammation?....Pages 135-158
Front Matter....Pages 159-159
Exercise Therapy for COPD: How Is Exercise Therapy Significant?....Pages 161-178
Nutritional Therapy for COPD: What Is the Present State of Nutritional Therapy and Is There a Possibility of Developing New Drugs?....Pages 179-194
Long-Term Oxygen Therapy (or Home Oxygen Therapy) for COPD: The Present State and Future Problems....Pages 195-210
Bronchodilators for COPD: At What Stage Should Therapeutic Intervention Be Initiated?....Pages 211-243
Inhaled Corticosteroids for COPD: Are Inhaled Corticosteroids Required in the Management of COPD?....Pages 245-266
New Anti-inflammatory Drugs for COPD: Is There a Possibility of Developing Drugs That Can Fundamentally Suppress Inflammation?....Pages 267-278
Exacerbation of COPD: Why Do Exacerbations of COPD Attract Attention? Are There Any Preventive Methods?....Pages 279-295
Front Matter....Pages 297-297
The Asthma–COPD Overlap Syndrome (ACOS): What Is the Significance COPD Associated with Asthma?....Pages 299-311
Combined Pulmonary Fibrosis and Emphysema (CPFE): Which Symptom, Fibrosis or Emphysema, Should Be Treated Preferentially? Or Should Both Be Treated Simultaneously?....Pages 313-332
Association of COPD and Lung Cancer: How Does COPD Management Change the Outcome of Treatment of Lung Cancer?....Pages 333-352

✦ Subjects

Pneumology/Respiratory System