Chronic Obstructive Pulmonary Disease

✍ Scribed by Steve Rennard, Bartolome Celli, Klaus Rabe

• Publisher: Wiley-Blackwell
• Year: 2007
• Tongue: English
• Leaves: 916
• Edition: 1
• Category: Library

✦ Synopsis

The only international clinical textbook for COPD – one of the top 5 causes of death and disability worldwide

• The only COPD textbook to include the latest national and international guidelines and the newer therapeutic agents in COPD treatment
• International team of contributors covers all aspects of COPD – from physiology and epidemiology to diagnosis and treatment
• Everything the busy physician needs to understand, diagnose and treat the COPD patient:

  - Structure and physiology of the respiratory system - Clinical considerations and allied conditions - Therapy (including current and developing treatments) - Diagnostic tests used in daily practice

✦ Table of Contents

Chronic Obstructive Pulmonary Disease......Page 5
Contents......Page 7
Contributors......Page 10
Preface......Page 16
Section 1: Physiology......Page 17
1 Structure–Function Relationships: The Pathophysiology of Airflow Obstruction......Page 19
2 The Physiology of Breathlessness......Page 36
3 The Physiology of Muscle......Page 42
4 Exercise Limitations and Cardiopulmonary Exercise Testing in Copd......Page 56
5 Clinical Assessment of Control of Breathing......Page 79
6 Physiology and Pathobiology of the Lung Circulation......Page 91
7 Sleep In Patients With Copd......Page 96
8 The Physiology of Cough......Page 106
9 The Physiology of Gas Exchange......Page 118
Section 2: COPD and allied conditions......Page 131
10 The Natural History of Copd......Page 133
11 Cystic Fibrosis......Page 140
12 Bronchiectasis and Copd......Page 155
13 Obliterative Bronchiolitis......Page 164
14 Asthma......Page 170
15 Copd: Clinical Presentation and Evaluation......Page 183
16 Monitoring and Outcomes......Page 197
Section 3: Host Defences and Inflammation......Page 205
17 Mucociliary Clearance......Page 207
18 Mucosal Immunity......Page 217
19 Copd and Pulmonary Surfactant......Page 228
20 The Macrophage and Its Role in the Pathogenesis of Copd......Page 235
21 Eosinophils and Copd......Page 249
22 Airway Epithelial Defence, Repair and Regeneration......Page 261
23 The Role of The Neutrophil In The Pathogenesis of Copd......Page 271
24 Lymphocytes......Page 285
25 Cytokines......Page 291
26 Leukotrienes In Copd: The Unexploited Potential......Page 301
27 Cigarette Smoking, Emphysema and Lung Endothelium......Page 316
28 Mesenchymal Cells of the Lung......Page 324
Section 4: Pathogenesis......Page 333
29 Lung Development......Page 335
30 Animal Models......Page 357
31 Proteinases and Copd......Page 365
32 Oxidants......Page 391
33 Cigarette Smoke-Induced Disease......Page 409
34 Copd and Air Pollution......Page 421
35 Viruses in Copd......Page 432
36 Bacteria......Page 443
37 Genetic Factors......Page 460
38 α1-Antitrypsin Deficiency......Page 471
39 Body Weight and Systemic Effects......Page 484
40 Lung Connective Tissue......Page 491
Section 5: Clinical Considerations and Complications......Page 505
41 Aerosols and Delivery Systems......Page 507
42 Gastro-Oesophageal Reflux......Page 523
43 Upper Airway Diseases......Page 537
44 Acute Pulmonary Embolism......Page 552
45 Copd and Lung Cancer......Page 562
46 Infection Management and Airflow Obstruction......Page 570
47 Mechanical Ventilation For Exacerbation of Copd......Page 583
48 Comorbidity......Page 593
Section 6: Current and Future Treatment......Page 601
49 Primary Care......Page 603
50 Pulmonary Rehabilitation......Page 609
51 Social Support......Page 619
52 Long-Term Invasive Mechanical Ventilation......Page 625
53 Smoking Cessation......Page 632
54 Oxygen Therapy in Copd......Page 646
55 Surgical Therapy For Copd......Page 660
56 Anticholinergics in Copd......Page 681
57 β2-Agonists......Page 693
58 Corticosteroids......Page 709
59 Phosphodiesterase 4 Inhibitors In The Treatment of Copd......Page 732
60 Antibiotic Therapy in Patients With Copd......Page 752
61 Antioxidants......Page 771
62 Mucolytics For Copd......Page 780
63 End-of-Life and Palliative Care for Patients With Copd......Page 793
64 Economic Burden of Copd......Page 803
65 Pharmacoepidemiology of Copd......Page 816
66 Social and Behavioural Impact of Copd … Research Opportunities......Page 829
67 Guidelines......Page 835
Section 7: Pharmacotherapy: Developing Therapies......Page 845
68 Protease Inhibitors......Page 847
69 Retinoids......Page 869
70 Chemokines in Copd......Page 883
Index......Page 891
Colour Plate Section Falls Between Pp. 354 and 355......Page 371