Chronic nicotine treatment partly protects against the 1-methyl-4-phenyl-2, 3, 6-tetrahydropyridine-induced degeneration of nigrostriatal dopamine neurons in the black mouse
✍ Scribed by JANSON, A. M. ;FUXE, K. ;SUNDSTRÖM, E. ;AGNATI, L. F. ;GOLDSTEIN, M.
- Book ID
- 114869391
- Publisher
- John Wiley and Sons
- Year
- 1988
- Tongue
- English
- Weight
- 184 KB
- Volume
- 132
- Category
- Article
- ISSN
- 0001-6772
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Evidence exists for a negative correlation between Parkinson's disease and smoking. The present and previous studies indicate that nicotine treatment can markedly alter the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced neurotoxicity in the black mouse based on biochemical determination
## Abstract Administration of the neurotoxicant 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) to C57BL/6 mice targets nigrostriatal dopaminergic neurons, leading to cell death and the depletion of striatal dopamine. After MPTP lesioning in young adult mice, surviving nigrostriatal dopaminergi