Chronic myeloid leukemia with an e13a3 BCR-ABL fusion: Benign course responsive to imatinib with an RT-PCR advisory

Isolated thrombocytosis as first sign of

Isolated thrombocytosis as first sign of chronic myeloid leukemia with e6a2 BCR/ABL fusion transcript, JAK2 negativity and complete response to imatinib

✍ Massimo Breccia; Laura Cannella; Daniela Diverio; Paola Streponi; Mauro Nanni; C 📂 Article 📅 2008 🏛 Elsevier Science 🌐 English ⚖ 91 KB

Since very few unusual BCR/ABL fusion transcripts in chronic myeloid leukemia have been reported, no clear evidence exists concerning their clinical and prognostic implications. We describe here a CML case with normal karyotype at standard cytogenetics and an atypical e6a2 BCR/ABL fusion transcript,