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Chronic Myeloid Leukemia (CML) in Children: Classical and Newer Therapeutic Approaches

โœ Scribed by Ampatzidou, Maria; Papadhimitriou, Stefanos I.; Goussetis, Evgenios; Panagiotou, John P.; Papadakis, Vassilios; Polychronopoulou, Sophia

Book ID
118018389
Publisher
Informa plc
Year
2012
Tongue
English
Weight
188 KB
Volume
29
Category
Article
ISSN
0888-0018

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## Abstract Chronic myeloid leukemia (CML) is a hematopoietic stem cell disorder caused by the oncogenic activity of the Bcrโ€Abl protein, a deregulated tyrosine kinase. Calcium may act directly on cellular enzymes and in conjunction with other cellular metabolites, such as cyclic nucleotides, to re