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Chronic Myelogenous Leukemia with the e6a2 BCR-ABL and Lacking Imatinib Response: Presentation of Two Cases

✍ Scribed by Vefring, Hege K.; Gruber, Franz X.E.; Wee, Line; Hovland, Randi; Hjorth-Hansen, Henrik; Gedde Dahl, Tobias; Meyer, Peter

Book ID
120173433
Publisher
S. Karger AG
Year
2009
Tongue
English
Weight
272 KB
Volume
122
Category
Article
ISSN
0001-5792

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Isolated thrombocytosis as first sign of chronic myeloid leukemia with e6a2 BCR/ABL fusion transcript, JAK2 negativity and complete response to imatinib
✍ Massimo Breccia; Laura Cannella; Daniela Diverio; Paola Streponi; Mauro Nanni; C πŸ“‚ Article πŸ“… 2008 πŸ› Elsevier Science 🌐 English βš– 91 KB

Since very few unusual BCR/ABL fusion transcripts in chronic myeloid leukemia have been reported, no clear evidence exists concerning their clinical and prognostic implications. We describe here a CML case with normal karyotype at standard cytogenetics and an atypical e6a2 BCR/ABL fusion transcript,