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Chronic myelogenous leukemia: mechanisms underlying disease progression

✍ Scribed by Shet, A S; Jahagirdar, B N; Verfaillie, C M

Book ID
110055137
Publisher
Nature Publishing Group
Year
2002
Tongue
English
Weight
250 KB
Volume
16
Category
Article
ISSN
0887-6924

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## Abstract The expression of the chimeric __BCR/ABL1__ fusion gene resulting from t(9;22)(q34;q11) in chronic myelogenous leukemia (CML) is necessary for malignant transformation, but not sufficient to maintain disease progression. The appearance of various chromosomal and molecular alterations in