Chronic Lymphocytic Leukemia

✍ Scribed by Michael Hallek, Barbara Eichhorst, Daniel Catovsky

• Publisher: Springer International Publishing
• Year: 2019
• Tongue: English
• Leaves: 171
• Series: Hematologic Malignancies
• Edition: 1st ed.
• Category: Library

✦ Synopsis

This book summarizes current knowledge on chronic lymphocytic leukemia (CLL), taking into account the most recent research. All aspects are considered, including pathophysiology, clinical presentation, diagnosis, prognosis, treatment, follow-up, and complications and their management. Readers will find important information on the various prognostic markers as well as practical guidance on the use of different diagnostic procedures. A key focus of the book is the changing treatment paradigm in CLL as progress in understanding of pathogenesis and pathophysiology leads to the identification of new potential therapeutic targets. General treatment concepts are clearly described, and it is explained how choice of treatment for CLL depends on stage, age, and performance status as well as specific genetic aberrations. In addition, frontline therapeutic strategies for disease relapse, including allogeneic stem cell transplantation, are reported. Looking beyond CLL, the diagnosis and therapy of T-cell prolymphocytic leukemia and T-cell large granular lymphocyte leukemia, two rare CLL-related entities, are addressed.

✦ Table of Contents

Front Matter ....Pages i-vi
Front Matter ....Pages 1-1
Chronic Lymphocytic Leukemia: Who, How, and Where? (Lydia Scarfò, Paolo Ghia)....Pages 3-17
Front Matter ....Pages 19-19
Laboratory Diagnosis of Chronic Lymphocytic Leukaemia (Andy C. Rawstron, Ruth M. de Tute, Roger G. Owen, Peter Hillmen)....Pages 21-35
Front Matter ....Pages 37-37
The Clinical Presentation of CLL (Daniel Catovsky, Monica Else, David Oscier)....Pages 39-50
Front Matter ....Pages 51-51
Prognostic Markers (Anna Schuh)....Pages 53-65
Front Matter ....Pages 67-67
Guidelines for Diagnosis, Indications for Treatment, Response Assessment, and Supportive Management of Chronic Lymphocytic Leukemia: The 2018 Update (Barbara Eichhorst, Michael Hallek)....Pages 69-77
Initial Therapy of Chronic Lymphocytic Leukemia (Barbara Eichhorst, Othman Al-Sawaf, Michael Hallek)....Pages 79-96
CLL with Del (17p)/TP53 Mutation (Eugen Tausch, Stephan Stilgenbauer)....Pages 97-106
Treatment of Relapsed and Refractory Chronic Lymphocytic Leukemia (Tadeusz Robak)....Pages 107-119
Front Matter ....Pages 121-121
Autoimmune Cytopenia in Chronic Lymphocytic Leukemia (Carol Moreno, Carolina Cuellar, Eva Puy Vicente)....Pages 123-136
Richter Syndrome (Adalgisa Condoluci, Davide Rossi)....Pages 137-151
Front Matter ....Pages 153-153
Prolymphocytic Leukaemia (Claire Dearden)....Pages 155-165
Large Granular Lymphocyte Leukemia (Jan Dürig)....Pages 167-179

✦ Subjects

Medicine & Public Health; Hematology; Oncology