Chronic Lymphocytic Leukemia

✍ Scribed by F. Melchers (auth.)

• Publisher: Springer-Verlag Berlin Heidelberg
• Year: 2005
• Tongue: English
• Leaves: 191
• Series: Current Topics in Microbiology and Immunology 294
• Edition: 1
• Category: Library

✦ Synopsis

Chronic lymphocytic leukaemia (CLL) is the most common leukaemia in the Western world. It is also the prototype of B-cell chronic lymphoid malignancies and of their ramifications within the fields of hematology, immunology and oncology. For a long time the Cinderella of lymphoid malignancies CLL has now become the focus of major interest and an increasing number of investigators from different areas, including genetics, molecular biology, basic and applied immunology are becoming actively engaged in the investigation of CLL. Clinicians are considering CLL as a very interesting target of many projects which aim at translating the new and exciting developments of basic science into effective new approaches to the patient.

✦ Table of Contents

B Cell Development and Its Deregulation to Transformed States at the Pre-B Cell Receptor-Expressing Pre-BII Cell Stage....Pages 1-17
Gene Expression Patterns in Human and Mouse B Cell Development....Pages 19-29
New Insights into the Phenotype and Cell Derivation of B Cell Chronic Lymphocytic Leukemia....Pages 31-49
Chronic Lymphocytic Leukemia: Molecular Genetics and Animal Models....Pages 51-70
What Do Somatic Hypermutation and Class Switch Recombination Teach Us About Chronic Lymphocytic Leukaemia Pathogenesis?....Pages 71-89
Chronic Lymphocytic Leukaemia: A Review of the Immuno-architecture....Pages 90-107
Clinical and Laboratory Parameters That Define Clinically Relevant B-CLL Subgroups....Pages 109-133
Differential Effects on CLL Cell Survival Exerted by Different Microenvironmental Elements....Pages 135-145
Genotypic Prognostic Markers....Pages 147-164
Chronic Lymphocytic Leukaemia: Clinical Translations of Biological Features....Pages 165-185

✦ Subjects

Cancer Research