Chronic iron overload enhances inducible nitric oxide synthase expression in rat liver
✍ Scribed by Pamela Cornejo; Patricia Varela; Luis A. Videla; Virginia Fernández
- Book ID
- 116789951
- Publisher
- Elsevier Science
- Year
- 2005
- Tongue
- English
- Weight
- 617 KB
- Volume
- 13
- Category
- Article
- ISSN
- 1089-8603
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📜 SIMILAR VOLUMES
Hepatic injury and chronic wounding are characterized by increased synthesis of extracellular matrix proteins including hyaluronan (HA). Recently, it has been recognized that low-molecular-weight fragments of HA, but not native HA (e.g., high-molecular-weight HA), induce inflammatory gene expression
To clarify the pathogenesis of hepatic iron toxicity, we investigated the effect of chronic dietary iron overload on the expression of several genes in rat liver. After 10 wk of iron treatment, when only minor histological features of liver damage were appreciable, the level of pro-a.JI)-collagen mR