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Chronic haloperidol affects striatal D2-dopamine receptor reappearance after irreversible receptor blockade

✍ Scribed by Emilio Merlo Pich; Fabio Benfenati; Costanza Farabegoli; Kjell Fuxe; Emanuel Meller; Marie Aronsson; Menek Goldstein; Luigi F. Agnati

Book ID: 115797840
Publisher: Elsevier Science
Year: 1987
Tongue: English
Weight: 466 KB
Volume: 435
Category: Article
ISSN: 0006-8993
DOI: 10.1016/0006-8993(87)91595-2

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## Abstract We studied the in vitro electrical activity of rat neostriatal neurons following chronic neuroleptic treatment. In haloperidol‐treated rats, unlike naive animals, activation of neostriatal D2 dopamine receptors induced a potent presynaptic inhibition of glutamate‐mediated excitatory syn