Chronic granulocytic leukemia: Reassessment of morphologic and cytogenetic characteristics in Ph1-positive and Ph1-negative cases
โ Scribed by Domnita Crisan; Joan C. Mattson; A. Al-Saadi
- Book ID
- 114791428
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 629 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0902-4441
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract A female patient with chronic myelocytic leukemia (CML) in chronic phase after busulfan and interferon treatment had four different cell lines in her bone marrow. In addition to cells with a normal karyotype there were cells with the Philadelphia chromosome (Ph^1^), cells with trisomy 8
A 23-year-old man developed Ph'-positive chronic myelogenous leukemia in 1966. After two short courses of busulfan not associated with severe myelosuppression, the frequency of Ph'-positive metaphases in his bone marrow was 40%. Over the next eight years, he remained hematologically stable without f