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Chronic food restriction up-regulates 11-β-hydroxysteroid dehydrogenase

✍ Scribed by Sledzinski, Tomasz ;Turyn, Jacek ;Stelmanska, Ewa ;Presler, Malgorzata ;Klimek, Jerzy ;Swierczynski, Julian

Book ID
111489597
Publisher
Walter de Gruyter GmbH
Year
2011
Tongue
English
Weight
408 KB
Volume
6
Category
Article
ISSN
2391-5412

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## Abstract Renal 11β‐hydroxysteroid dehydrogenase 2 (HSD2) catalyzes the conversion of active glucocorticoids to inert 11β‐keto compounds, thereby preventing the illicit binding of these hormones to mineralocorticoid receptors (MRs) and, thus, conferring aldosterone specificity. Absence or inhibit