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11β-Hydroxysteroid dehydrogenase type 1 regulates insulin and glucagon secretion in pancreatic islets

✍ Scribed by A. Swali; E. A. Walker; G. G Lavery; J. W. Tomlinson; P. M. Stewart


Publisher
Springer
Year
2008
Tongue
English
Weight
326 KB
Volume
51
Category
Article
ISSN
0012-186X

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Glucocorticoid therapy forms a crucial first-line treatment for childhood acute lymphoblastic leukemia (ALL). However, glucocorticoid resistance is a therapeutic problem with an unclear molecular mechanism. 11beta-Hydroxysteroid dehydrogenase-1 (11beta-HSD1) is expressed in glucocorticoid target tis