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Chronic ethanol administration decreases the ligand binding properties and the cellular content of the mannose 6-phosphate/insulin-like growth factor II receptor in rat hepatocytes

✍ Scribed by James Haorah; Daniel L. McVicker; James C. Byrd; Richard G. MacDonald; Terrence M. Donohue Jr.


Book ID
113993002
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
227 KB
Volume
63
Category
Article
ISSN
0006-2952

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The ability of acute insulin treatment to elicit a redistribution of the liver insulin-like growth factor-II/ mannose 6-phosphate (IGF-II/M6P) receptor has been studied in rats, using cell fractionation. Injection of insulin (0.4 -50 g) led to a time-and dose-dependent decrease in IGF-II binding act