𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Chronic delta hepatitis in haemophiliacs

✍ Scribed by Dr. Andreas Gerritzen; Hans Brackmann; Birgit Van Loo; Gudrun Nies; Christiane Ruland; Gertrud Spiegelberg; Ursula Hammerstein

Book ID
102379912
Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
339 KB
Volume
34
Category
Article
ISSN
0146-6615

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✦ Synopsis

Abstract

The seroepidemiological profile of HBV and HDV was investigated in 640 male haemophiliacs. Twenty‐seven of forty‐four HBsAg carriers were anti‐HDV‐lgG positive, 22 were also anti‐HDV‐IgM positive. A markedly lower prevalence of HDV infection was found in patients with anti‐HBc in the absence of HBsAg and anti‐HBs (6/41). Repeated detection of anti‐HDV‐IgM in 5/41 individuals of this group indicates that circulating HBsAg is not an absolute prerequisite for chronic HDV infection.

Overall, chronically active HDV infection was detected more frequently in quiescent than in active chronic HBV infections. Anti‐HDV‐lgM was not detected in the absence of anti‐HDV‐lgG antibodies. Anti‐HDV‐IgG may disappear after resolution of HDV infection, as indicated by the low prevalence (1/42) in such individuals with past HBV infection as well as by loss of anti‐HDV‐lgG observed in two patients.

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