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Chronic carbamazepine selectively downregulates cytosolic phospholipase A2 expression and cyclooxygenase activity in rat brain

✍ Scribed by Sandra Ghelardoni; York A Tomita; Jane M Bell; Stanley I Rapoport; Francesca Bosetti

Book ID: 119196430
Publisher: Elsevier Science
Year: 2004
Tongue: English
Weight: 293 KB
Volume: 56
Category: Article
ISSN: 0006-3223
DOI: 10.1016/j.biopsych.2004.05.012

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## Abstract Previously we have reported that thrombin induces inflammatory mediators in brain glial cells (Ryu et al. 2000. J Biol Chem 275:29955). In the present study, we found that thrombin induced a negative regulator of a cytokine signaling molecule, cytokine‐induced SH2 protein (CIS), in rat