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Chronic antagonist infusion does not increase morphine antinociception in rat spinal cord

โœ Scribed by Craig W. Stevens; Tony L. Yaksh


Book ID
115797169
Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
211 KB
Volume
425
Category
Article
ISSN
0006-8993

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We have shown previously that systemic chronic morphine treatment causes down-regulation of spinal adenosine A1 receptors in rats. Recently, we have found that chronic supraspinal morphine treatment also causes this effect. In the present study, we investigated whether chronic spinal morphine treatm