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Chronic infusion of clonidine does not alleviate spontaneous morphine withdrawal symptoms in rats

โœ Scribed by J. W. Laan; C. Jansen van't Land


Publisher
Springer
Year
1992
Tongue
English
Weight
685 KB
Volume
108
Category
Article
ISSN
0033-3158

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We have shown previously that systemic chronic morphine treatment causes down-regulation of spinal adenosine A1 receptors in rats. Recently, we have found that chronic supraspinal morphine treatment also causes this effect. In the present study, we investigated whether chronic spinal morphine treatm