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Chronic administration of the enkephalinase inhibitor SCH 34826 reduces D-1 dopamine receptor density in rat striatum

โœ Scribed by E. Ongini; M. Trampus; K. Varani; P.A. Borea

Book ID
115885984
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
92 KB
Volume
183
Category
Article
ISSN
0014-2999

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Chronic haloperidol administration incre
Chronic haloperidol administration increases the density of D2 dopamine receptors in the medial prefrontal cortex of the rat
โœ A. John MacLennan; Stella Atmadja; Nancy Lee; H. C. Fibiger ๐Ÿ“‚ Article ๐Ÿ“… 1988 ๐Ÿ› Springer ๐ŸŒ English โš– 299 KB

Rats received haloperidol (1.3-1.5 mg/kg/day) via their drinking water for 21 weeks. At the end of this period the density of D2 dopamine receptors and their affinity for [3H]-spiperone were measured in the striatum and medial prefrontal cortex. The chronic haloperidol treatment increased the densit