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Chronic administration of nicotine fails to alter the MPTP-induced neurotoxicity in mice

โœ Scribed by Fung, Yiu K.; Fiske, Lori A.; Lau, Yuen-Sum


Book ID
122096479
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
343 KB
Volume
22
Category
Article
ISSN
0306-3623

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Chronic L-deprenyl does not alter the re
โœ Dr. H. L. Wiener; A. Hashim; A. Lajtha; H. Sershen ๐Ÿ“‚ Article ๐Ÿ“… 1989 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 365 KB

The present study examined the effect of chronic Ldeprenyl on dopaminergic terminal function after mouse striatal terminals were lesioned with l-methyl-4-phenyI-l,2,3,64etrahydropyridine (MPTP; 2 X 30 mg/kg s.c.). In the MPTP-lesioned mice, the level of dopamine was decreased by 59% 1 week after MPT