Chronic L-deprenyl does not alter the restoration of striatal dopamine in MPTP-lesioned mice

✍ Scribed by Dr. H. L. Wiener; A. Hashim; A. Lajtha; H. Sershen

• Publisher: John Wiley and Sons
• Year: 1989
• Tongue: English
• Weight: 365 KB
• Volume: 23
• Category: Article
• ISSN: 0360-4012
• DOI: 10.1002/jnr.490230312

✦ Synopsis

The present study examined the effect of chronic Ldeprenyl on dopaminergic terminal function after mouse striatal terminals were lesioned with l-methyl-4-phenyI-l,2,3,64etrahydropyridine (MPTP; 2 X 30 mg/kg s.c.). In the MPTP-lesioned mice, the level of dopamine was decreased by 59% 1 week after MPTP administration and by 22% at 16 weeks. Chronic administration of L-deprenyl (0.1 mg/kg, once weekly for up to 16 weeks) did not alter striatal dopamine metabolism, although monoamine oxidase B activity was reduced by 50% during this 16-week period, and did not alter the rate of restoration of the level of striatal dopamine.