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Chromosome studies in patients with T-CLL chronic lymphocytic leukemia and expansions of granular lymphocytes

✍ Scribed by B. Dallapiccola; G. Alimena; L. Chessa; R. Gastaldi; G. De Rossi; G. Semenzato; I. Quinti; F. Pandolfi

Publisher
John Wiley and Sons
Year
1984
Tongue
French
Weight
605 KB
Volume
34
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

Chromosome analyses were carried out in eight patients with lymphoproliferative disorders of mature T and NK cells. Three cases were characterized by an abnormal expansion of granular lymphocytes (GL), one by a lymphoma of GL with leukemic spread, and four by an OKT4‐T‐CLL In four patients cytogenetic studies were performed on bone marrow cells; in seven patients peripheral blood lymphocytes were examined by either direct preparations or PHA‐stimulated cultures. Six patients displayed a normal karyotype. Two cases belonging to the OKT4‐T‐CLL group had a chromosome number ranging from 44 to 47, with multiple numerical and structural clonal anomalies. Clonal anomalies could be a feature of patients with the more aggressive clinical course.

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