✦ LIBER ✦

A pilot study of epirubicin and chlorambucil in the treatment of chronic lymphocytic leukemia (CLL)

✍ Scribed by Dr G. M. Smith; J. A. Child; D. W. Milligan; M. A. McEvoy; J. A. Murray

Publisher: John Wiley and Sons
Year: 2006
Tongue: English
Weight: 428 KB
Volume: 9
Category: Article
ISSN: 0278-0232
DOI: 10.1002/hon.2900090606

No coin nor oath required. For personal study only.

✦ Synopsis

In a pilot study of the combination of epirubicin and chlorambucil in the treatment of chronic lymphocytic leukemia (CLL), 10 patients with advanced or progressive disease were treated in four centres. Up to a total of 15 courses in individual patients were given. Toxicity was relatively mild with nausea due to epirubicin being the most commonly reported side-effect. One patient developed a probable septicemia during a period of neutropenia. In another patient who died from probable Pneumocystis carinii pneumonia (PCP) after only one course of therapy, death could not be regarded as necessarily treatment-related. In seven previously untreated patients, one complete response and four partial remissions were seen. All three previously treated patients showed partial remissions KEY WORDS Epirubicin Chlorambucil Chronic lymphocytic leukemia

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