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Chromosome rearrangements at telomeric level in hematologic disorders

✍ Scribed by Paola Temperani; Francesca Giacobbi; Giovanna Gandini; Umberto Torelli; Giovanni Emilia

Book ID: 113253418
Publisher: Elsevier Science
Year: 1995
Tongue: English
Weight: 686 KB
Volume: 83
Category: Article
ISSN: 0165-4608
DOI: 10.1016/0165-4608(94)00222-w

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## Abstract Telomeres are the ends of chromosomes and protect them from degradation and fusion. As such, their stability is required for normal cellular function. Telomere dysfunction is found often at the origin of cellular transformation and contributes to the onset of genomic instability, a hall