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Initiation of telomere-mediated chromosomal rearrangements in cancer

✍ Scribed by Sabine Mai

Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 432 KB
Volume: 109
Category: Article
ISSN: 0730-2312
DOI: 10.1002/jcb.22501

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✦ Synopsis

Abstract

Telomeres are the ends of chromosomes and protect them from degradation and fusion. As such, their stability is required for normal cellular function. Telomere dysfunction is found often at the origin of cellular transformation and contributes to the onset of genomic instability, a hallmark of cancer cells. In this article, I discuss current data and concepts on telomere‐mediated chromosomal rearrangements in cancer. J. Cell. Biochem. 109: 1095–1102, 2010. © 2010 Wiley‐Liss, Inc.

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