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Chromosome patterns of nontransformed variants from chemically transformed Balb/3T3 cells

✍ Scribed by C. D. Olinici; C. H. Evans; J. A. DiPaolo

Publisher
John Wiley and Sons
Year
1974
Tongue
English
Weight
527 KB
Volume
83
Category
Article
ISSN
0021-9541

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✦ Synopsis

Abstract

Nine variant cell lines isolated from cloned 7,12‐dimethylbenz(a) ‐ahthracene transformed Balb/3T3 mouse cells by treatment with FUdR had growth parameters closely resembling nontransformed cells. Chromosome analysis of the variant lines demonstrated that six variants had a diminished number and three variants had an increased number of chromosomes compared to the parental transformed cell line. All variants had unique marker chromosomes not present in the parental transformed Balb/3T3 cells. The distribution of marker chromosomes and heterochromatin suggested that the initial event in variant formation was a reduction in chromosome number with a subsequent polyploidization of the reduced chromosome complement.

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