Chromosome microdissection identifies DNA sequence amplification in human ovarian carcinoma
β Scribed by C.B. Cargile; X.Y. Guan; A. Elkahloun; P.S. Meltzer; J.M. Trent
- Book ID
- 113253855
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 163 KB
- Volume
- 84
- Category
- Article
- ISSN
- 0165-4608
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## Abstract Alterations of chromosome bands 19p13 and 19q13 in the form of added extra material of unknown origin are among the most frequent cytogenetic changes in ovarian carcinomas. To investigate the chromosomal composition of the 19p+ and/or 19q+ markers, we selected for examination 26 ovarian
## Abstract Alterations of chromosome 19 are among the most frequent cytogenetic changes in ovarian carcinomas. They usually occur as added extra material of unknown origin to 19p or, less frequently, 19q but sometimes as homogeneously staining regions. The precise nature of these markers, i.e., ex
Chromosome microdissection-fluorescence in situ hybridization and comparative genomic hybridization (CGH) were performed in parallel to identify the native location of amplified DNA in a human non-small cell lung cancer (NSCLC) cell line exhibiting a homogeneously staining region (hsr) and double mi