Chromosome imprinting: Flexible X
β Scribed by Greaves, Sarah
- Book ID
- 109951830
- Publisher
- Nature Publishing Group
- Year
- 2004
- Tongue
- English
- Weight
- 90 KB
- Volume
- 5
- Category
- Article
- ISSN
- 1471-0056
- DOI
- 10.1038/nrg1286
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Laird et al. (1987) hypothesized that there are at least four cis-acting alleles or 'chromosome states' at Xq27 that increasingly delay replication at this chromosomal area resulting in its increasing fragility in vitro. When on the inactive X chromosome, the proposed third ('mutated') allele can
The conflict theory of genomic imprinting predicts that imprinted genes are growth enhancing when paternally expressed and growth suppressing when maternally expressed. The expression pattern of autosomal imprinted genes generally fits these predictions. However, the conflict theory cannot easily ac