Chromosome imprinting and the mammalian X chromosome
β Scribed by Chandra, H. Sharat; Brown, Spencer W.
- Book ID
- 109694055
- Publisher
- Nature Publishing Group
- Year
- 1975
- Tongue
- English
- Weight
- 427 KB
- Volume
- 253
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/253165a0
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None of the up to now localized and expressed oncogenes maps to the mammalian X chromosome. This fact is discussed in the light of a trans-acting regulation mechanism for oncogenes. Such a specific regulation mechanism is demonstrated here for a qualitative change--i.e., varying timing of DNA-replic
Laird et al. (1987) hypothesized that there are at least four cis-acting alleles or 'chromosome states' at Xq27 that increasingly delay replication at this chromosomal area resulting in its increasing fragility in vitro. When on the inactive X chromosome, the proposed third ('mutated') allele can