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Chromosome Alteration and Tumour Inhibition by Nitrogen Mustards: the Hypothesis of Cross-linking Alkylation

✍ Scribed by BIESELE, J. J.; PHILIPS, F. S.; THIERSCH, J. B.; BURCHENAL, J. H.; BUCKLEY, SONJA M.; STOCK, C. C.


Book ID
109563666
Publisher
Nature Publishing Group
Year
1950
Tongue
English
Weight
266 KB
Volume
166
Category
Article
ISSN
0028-0836

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## Abstract The concentration of ^3^H‐aniline mustard in two tumour lines has been measured and the level of binding of the drug to DNA followed for 48 hours after intraperitoneal injection. Although the two tumour lines differ a hundred‐fold in their sensitivity to this alkylating agent, no good c