Chromosome abnormalities in malignant histiocytosis

✍ Scribed by Yasuhiko Kaneko; Masahiro Kikuchi; Akinori Ishihara; Rokuo Abe; Shojiro Takayama; Masaharu Sakurai

• Publisher: John Wiley and Sons
• Year: 1985
• Tongue: English
• Weight: 939 KB
• Volume: 56
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/1097-0142(19850701)56:1<144::aid-cncr2820560123>3.0.co;2-c

✦ Synopsis

Chromosome and pathologic studies were performed on two patients (a 12-year-old boy and a 62-yearold woman) with malignant histiocytosis (MH). Both patients had chromosome abnormalities in their neoplastic cells: the boy's karyotype was 45,Xp+,-Y,9p+,18q-, and the woman's 48,XX+16, inv( l),mar(5),6p-,IOp+,l tq+,i(lh),+i( 18s). The boy had typical clinical and pathologic findings of MH, and died without achieving remission by chemotherapy. At the initial stage the woman had the clinical and hematologic findings of MH. Chemotherapy was given, but had no beneficial effects. At the terminal stage the bone marrow (BM) biopsy and aspirate, and the autopsy findings, were consistent with those of non-Hodgkin lymphoma, diffuse large cell type, although some histiocytes or abnormal cells in monocyte-macrophage lineage remained in the BM and the autopsied lymph nodes. This study and a review of data on six other cases have failed to establish any specific chromosome changes in MH.

Cancer 56:144-151, 1985.

ALIGNANT HIsTiocYTosis (MH), also referred to M as histiocytic medullary reticulosis (HMR), is a systemic disease characterized by diffuse neoplastic proliferation of histiocytes and their precursors in various tissues including lymph nodes (LNs), bone marrow (BM), liver, and spleen.'-3 MH is considered to be a heterogeneous group of diseases in regard to the clinical course as well as the response to chem~therapy.~.' Chromosome studies on leukemia and lymphoma have been done extensively, and have provided essential information regarding their biologic nature and classification! Data on chromosomes in MH, however, are Here, we describe the chromosome findings as well as the clinical, hematologic, and pathologic features in two patients with MH. We also summarize the chromosome pattern in MH from our cases and those in the l i t e r a t ~r e . ~-~