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Chromosome abnormalities from cyclophosphamide therapy in rheumatoid arthritis and progressive systemic sclerosis (scleroderma)

โœ Scribed by Sanford F. Tolchin; Dr Alan Winkelstein; Gerald P. Rodnan; Sylvia F. Pan; Howard R. Nankin


Publisher
John Wiley and Sons
Year
1974
Tongue
English
Weight
536 KB
Volume
17
Category
Article
ISSN
0004-3591

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## Levels of CAMP were decreased and cGMP increased in progressive systemic sclerosis (PSS) fibroblasts compared with normal fibroblasts. PSS cells took up unusually large quantities of Ca++. The epinephrineinduced increases in cAMP were diminished sixfold and epinephrine-induced Ca++ uptake was a