✦ LIBER ✦
Cyclic nucleotides and calcium transport in cultured dermal fibroblasts from progressive systemic sclerosis and rheumatoid arthritis patients
✍ Scribed by M. D. Grozdova; J. V. Khokhlova; A. F. Panasyuk; N. G. Guseva; T. M. Trofimova
- Publisher
- John Wiley and Sons
- Year
- 1984
- Tongue
- English
- Weight
- 569 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0004-3591
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✦ Synopsis
Levels
of CAMP were decreased and cGMP increased in progressive systemic sclerosis (PSS) fibroblasts compared with normal fibroblasts. PSS cells took up unusually large quantities of Ca++. The epinephrineinduced increases in cAMP were diminished sixfold and epinephrine-induced Ca++ uptake was abnormal in PSS cells. Considerable heterogeneity was observed in rheumatoid arthritis fibroblasts. Membrane-bound abnormalities in (PSS) cells may be of importance in the defective control of collagen production in progressive systemic sclerosis.