𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Chromosome abnormalities, clinical and morphological manifestations in metamorphosis of chronic myeloid leukemia

✍ Scribed by Éva Oläh; Attila Kiss; János Jakq

Publisher
John Wiley and Sons
Year
1980
Tongue
French
Weight
660 KB
Volume
26
Category
Article
ISSN
0020-7136

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Seventeen cases of chronic myeloid leukemia (CML) in metamorphosis have been investigated by cytogenetic methods. Six patients were studied in slow transformation and others in the terminal blastic phase of the disease. Of these, 3 cases were myeloid, 3 myelomonocytic, I megakaryoblastic, I promyelocytic and 4 lymphoid in their morphological and cytochemical appearance. Some correlation could be observed between the clinical, morphological, cytochemical and cytogenetic findings of the different subgroups. The results demonstrate the importance of chromosome investigations in the early diagnosis of metamorphosis and in distinguishing the different subgroups of the terminal stage of CML.

📜 SIMILAR VOLUMES

Chromosome abnormalities and clinical an
Chromosome abnormalities and clinical and morphologic manifestations of chronic myeloid leukemia
✍ E. L. Prigogina; E. W. Fleischman; M. A. Volkova; M. A. Frenkel 📂 Article 📅 1978 🏛 Springer 🌐 English ⚖ 650 KB

Forty cases of chronic myeloid leukemia (CML) were studied and subgroups of cases with similar chromosomal abnormalities in terminal stage were defined. Certain correlations were observed between the type of chromosomal changes, and clinical and morphologic manifestations of the disease: (1) It seem

Correlation between CD34 expression and
Correlation between CD34 expression and chromosomal abnormalities but not clinical outcome in acute myeloid leukemia
✍ Fruchart, Christophe; Lenormand, Bernard; Bastard, Christian; Boulet, Dominique; 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 482 KB 👁 2 views

The hemopoietic stem cell marker CD34 has been reported to be a useful predictor of treatment outcome in acute myeloid leukemia (AML). Previous data suggested that CD34 expression may be associated with other poor prognosis factors in AML such as undifferentiated leukemia, secondary AML (SAML), and

The prognosis for patients with chronic
The prognosis for patients with chronic myeloid leukemia who have clonal cytogenetic abnormalities in philadelphia chromosome-negative cells
✍ Michael W. N. Deininger; Jorge Cortes; Ron Paquette; Byung Park; Andreas Hochhau 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 380 KB

## Abstract ## BACKGROUND. Clonal cytogenetic abnormalities (CCA) were detected in Philadelphia chromosome (Ph)‐negative cells in some patients with chronic myeloid leukemia (CML) who attained a cytogenetic response to imatinib mesylate. In some patients, CCA/Ph‐negative status was associated with