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Chromosome aberrations in psoriatic patients treated with arsenic

✍ Scribed by I. Nordenson; S. Salmonsson; E. Brun; G. Beckman

Publisher
Springer
Year
1979
Tongue
English
Weight
309 KB
Volume
48
Category
Article
ISSN
0340-6717

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✦ Synopsis

A significantly increased frequency of chromosomal aberrations was found in lymphocytes from eight psoriatic patients previously treated with arsenic than in lymphocytes from eight psoriatics with no such previous treatment. In most patients the arsenic therapy was discontinued more than 15 years ago. In the arsenic-treated group a statistically significant heterogeneity was found with respect to the frequency of aberrations. The frequency of sister chromatid exchange was not increased in the arsenic-treated patients.

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Chromosome lesions detected in lymphocytes from 14 patients previously treated with melphalan. a bifunctional alkylating agent, have been analyzed on R-banded preparations. In comparison to controls, there was no significant increase of chromatid-type lesions, but chromosome-type lesions were quite