Bleomycin-induced chromosomal aberration
Bleomycin-induced chromosomal aberrations and sister chromatid exchanges in Down lymphocyte cultures
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K. Lijima; K. Morimoto; A. Koizumi; M. Higurashi; M. Hirayama
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Article
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1984
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Springer
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English
⚖ 419 KB
Peripheral blood lymphocytes from three patients with Down syndrome (DS; trisomy 21; aged 5-6 years) and three age-matched control children were studied for the induction of chromosomal aberrations and sister chromatid exchanges (SCEs). Cells in G0 were exposed to bleomycin (20-100 micrograms/ml) fo