✦ LIBER ✦

Chromosome 9p deletions identify an aggressive phenotype of clear cell renal cell carcinoma

✍ Scribed by Jeffrey La Rochelle; Tobias Klatte; Aditi Dastane; Nagesh Rao; David Seligson; Jonathan Said; Brian Shuch; Nazy Zomorodian; Fairooz Kabbinavar; Arie Belldegrun; Allan J. Pantuck

Publisher: John Wiley and Sons
Year: 2010
Tongue: English
Weight: 250 KB
Volume: 116
Category: Article
ISSN: 0008-543X
DOI: 10.1002/cncr.25279

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Microsatellite analysis reveals deletion

Microsatellite analysis reveals deletion of a large region at chromosome 8p in conventional renal cell carcinoma

✍ Dietlinde Schullerus; Rolf von Knobloch; Jerzy Chudek; Jutta Herbers; Gyula Kova 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 French ⚖ 83 KB 👁 2 views

Loss of heterozygosity (LOH) at chromosome 8p is associated with the progression of conventional (non-papillary) renal cell carcinomas (RCC). To determine the tumor suppressor gene locus, we carried out a deletion mapping of chromosome 8p at 10 microsatellite loci in 96 RCCs. LOH occurred in 32% of

Low frequency of HLA haplotype loss asso

Low frequency of HLA haplotype loss associated with loss of heterozygocity in chromosome region 6p21 in clear renal cell carcinomas

✍ Isabel Maleno; Miguel Angel Lopez Nevot; Barbara Seliger; Federico Garrido 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 French ⚖ 94 KB 👁 1 views

## Abstract HLA class I loss or downregulation is a widespread mechanism used by tumor cells to avoid tumor recognition by cytotoxic T lymphocytes favoring tumor immune escape. Multiple molecular mechanisms are responsible for these altered HLA class I tumor phenotypes. It has been described in dif

Biologic behavior of and p53 overexpress

Biologic behavior of and p53 overexpression in multifocal renal cell carcinoma of clear cell type : An immunohistochemical study correlating grading, staging, and proliferation markers

✍ Andrea Haitel; Helene G. Wiener; Ulrike Blaschitz; Michael Marberger; Martin Sus 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 213 KB 👁 2 views

## BACKGROUND. In the treatment of small renal cell carcinoma (RCC), there is controversy between radical and nephron-sparing surgical treatment because of the risk of tumor multifocality. The biologic behavior of multifocal RCC compared with that of unifocal RCC is not well investigated, and the

Allelic loss at the D9S171 locus on chro

Allelic loss at the D9S171 locus on chromosome 9p13 is associated with progression of papillary renal cell carcinoma

✍ Schraml, P.; M�ller, D.; Bednar, R.; Gasser, Th.; Sauter, G.; Mihatsch, M. J.; M 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 110 KB 👁 1 views

Papillary renal cell carcinomas (RCCs) have characteristic clinical and morphological features that separate them from the more common clear cell RCCs. The details of the molecular changes in papillary RCC progression are not well understood. In this study, four highly polymorphic microsatellite mar

Inactivation of the von Hippel–Lindau (V

Inactivation of the von Hippel–Lindau (VHL) tumour suppressor gene and allelic losses at chromosome arm 3p in primary renal cell carcinoma: Evidence for a VHL-independent pathway in clear cell renal tumourigenesis

✍ Steven C. Clifford; Amanda H. Prowse; Nabeel A. Affara; Charles H. C. M. Buys; E 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 149 KB 👁 2 views

Inactivation of tumour suppressor gene(s) (TSGs) on 3p appears to be a critical event in the pathogenesis of clear cell renal cell carcinoma (CC-RCC). Analysis of loss of heterozygosity (LOH) in sporadic RCC samples has implicated roles for TSGs in three specific regions of 3p in RCC development: (1

Loss of heterozygosity at chromosomes 8p

Loss of heterozygosity at chromosomes 8p, 9p, and 14q is associated with stage and grade of non-papillary renal cell carcinomas

✍ Schullerus, Dietlinde; Herbers, Jutta; Chudek, Jerzy; Kanamaru, Hiroshi; Kovacs, 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 92 KB 👁 2 views

In this study, 105 non-papillary renal cell carcinomas (RCCs) have been examined for allelic loss at the chromosome 8p12-21.1, 9p21, and 14q24.2-qter regions, each by two highly polymorphic microsatellites. Loss of heterozygosity (LOH) was detected at both chromosome 8p and 9p in 33 per cent of the