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Chromosome 17 involvement in neuroblastoma: An overview

✍ Scribed by N. Van Roy; P. van der Drift; M. Van Gele; A. Chan; G. Laureys; G. Opdenakker; L. Maertens; J. Vandesompele; R. Versteeg; F. Speleman


Book ID
114136724
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
137 KB
Volume
98
Category
Article
ISSN
0165-4608

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## Abstract In neuroblastoma, the most frequent genetic alteration is gain of chromosome arm 17q, which arises from unbalanced translocations. To document these genetic events more precisely, we performed an extensive study of chromosome 17 breakpoints in 27 neuroblastoma cell lines by using a comb

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Deletions of chromosome arm 1p and amplification of the MYCN oncogene are well-recognized genetic changes in neuroblastoma cells. Technical difficulties in cytogenetic analysis of this tumour have hampered the recognition of other recurring abnormalities, but recent use of molecular cytogenetic tech