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Chromosome 16 in primary prostate cancer: A microsatellite analysis

✍ Scribed by Iman Osman; Howard Scher; Guido Dalbagni; Victor Reuter; Zuo-Feng Zhang; Carlos Cordon-Cardo

Publisher: John Wiley and Sons
Year: 1997
Tongue: French
Weight: 93 KB
Volume: 71
Category: Article
ISSN: 0020-7136
DOI: 10.1002/(sici)1097-0215(19970516)71:4<580::aid-ijc12>3.0.co;2-g

No coin nor oath required. For personal study only.

✦ Synopsis

Cytogenetic and molecular genetic analyses of prostate cancer specimens have revealed nonrandom chromosomal deletions, affecting chromosomes 7q, 8p, 10q and 16q. Based on these data, we designed this study to further characterize the altered region(s) on chromosome 16 by evaluating 16 microsatellite markers on a population composed of 32 paired normal and primary prostatic tumor samples. The 16 microsatellites selected mapped to 11 distinct loci on 16q and 5 loci on 16p. No alterations were identified affecting 16p. However, 16 of 31 (51%) informative cases showed molecular alterations in at least one of the loci analyzed on 16q, consisting of 18 deletions and 11 bandshifts. Moreover, most of the deletions clustered at 6 microsatellite loci, mapping to the 16q22.1-23.1 region. Our results suggest that microsatellite alterations on the long arm of chromosome 16 are frequent events in prostate cancer, and that the 16q22.1-23.1 region might harbor a tumor suppressor gene involved in prostate cancer.

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