We report on a 10-year-old boy with a normal karyotype and a chromosome 13q14 deletion of the retinoblastoma gene (RB1) by fluorescence in situ hybridization (FISH). He showed subtle signs of overgrowth, including macrocephaly, hepatomegaly, and inguinal hernia. The boy also had cryptorchism and mil
Chromosome 14q+ in a retinoblastoma
β Scribed by D. K. Hossfeld
- Publisher
- John Wiley and Sons
- Year
- 1978
- Tongue
- French
- Weight
- 822 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0020-7136
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β¦ Synopsis
Abstract
A chromosome 14q+ was found in the tumor cells of a patient with sporadic, bilateral retinoβblastoma. Eightyβsix per cent of the metaphases contained the marker. Some metaphases showed a chromosome 6qβ in addition. The question of the specificity of such markers in lymphoid malignancies is raised.
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Cytogenetic, in situ hybridization, and molecular studies were performed in a case of T-cell-rich B-cell lymphoma. Demonstration of Ig gene rearrangements for both heavy and light chains confirmed the B-lineage restriction of the neoplastic cell population. Moreover, as expected in B-cell malignanci