Chromosome 12q heterozygosity is retained in i(12)p positive testicular germ tumor cells
β Scribed by A.Geyrts van Kessel; E. van Drunen; B. de Jong; J.W. Oosterhuis; A. Langevels; M.P. Mulder
- Book ID
- 113395727
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 92 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0922-3371
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## Abstract A chromosome 12βderived marker was seen in each of 3 testicular germ cell tumors that lacked the i(12p). An interesting feature of 2 of the markers was that the major part, including the centromere, of an acrocentric (a #13 and #14, respectively) was translocated onto 12p, resulting in
To identify common regions of deletion in human testicular germ cell tumors (TGCTs), we have screened tumors from 33 patients for loss of heterozygosity (LOH) using Southern blot analysis with 39 polymorphic markers covering 21 chromosome arms. Losses in more than 2 tumors and occurring at a frequen