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Chromosomal translocations and palindromic AT-rich repeats
β Scribed by Takema Kato; Hiroki Kurahashi; Beverly S Emanuel
- Book ID
- 116505540
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 473 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0959-437X
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We identified 10 members of a single family with mental retardation and microcephaly, one member having macrocephaly instead. The pedigree was best compatible with the segregation of a small translocation, despite results of previous cytogenetic studies in several relatives being apparently normal.
## Simple repeats are not found more abundantly at G/C-rich regions Three hundred and fifty cosmids from chromosome 7, previously analyzed for the presence of rare-cutting restriction enzyme sites, were analyzed for the presence of microsatellite sequences [(CA), or (CT), repeats]. Of these, 147 c