Chromosomal localization of the large subunit of mouse replication factor C in the mouse and human
β Scribed by A. C. Lossie; B. R. Haugen; W. M. Wood; S. A. Camper; D. F. Gordon
- Publisher
- Springer-Verlag
- Year
- 1995
- Tongue
- English
- Weight
- 243 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0938-8990
No coin nor oath required. For personal study only.
β¦ Synopsis
Mouse and human
Locus name: 140 kDa subunit of DNA replication factor C complex. This 5-subunit complex is a DNA-activated ATPase that complexes with proliferating cell nuclear antigen and DNA polymerase ~ to direct the synthesis of both the leading and lagging strands at the replication fork [1].
π SIMILAR VOLUMES
## Abstract Replication factor C (RFC) is a heteropentameric sliding clamp loader protein essential for processive synthesis of DNA by eukaryotic DNA polymerases Ξ΄ and Ο΅. To study the interaction of RFC with 3β² and 5β² ends of the DNA primer, we have developed chemical photocrosslinking assay using
We examined cDNAs of the catalytic subunit of DNA polymerase β£ (185 kDa), the 70 kDa subunit of replication protein A (single-stranded DNA-binding protein) and the 140 kDa subunit of replication factor C for mutations. Surgical specimens from 12 patients with sporadic colon cancer and normal mucosae
We report here the isolation and characterization of a cDNA from mouse thymus encoding the murine homolog of the protein product of the Syrian hamster Pcph proto-oncogene. The single open reading frame identified in the cDNA sequence encoded a protein predicted to have 428 amino acids, which shared