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Chromosomal insertion involving MLL in childhood acute myeloblastic leukemia (M4)

✍ Scribed by Lucie Lafay-Cousin; Valérie Soenen; Françoise Mazingue; Claude Preudhomme; Jean-Luc Laı̈; Joris Andrieux

Book ID: 113512305
Publisher: Elsevier Science
Year: 2004
Tongue: English
Weight: 259 KB
Volume: 150
Category: Article
ISSN: 0165-4608
DOI: 10.1016/j.cancergencyto.2003.08.006

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We describe a patient with acute myeloblastic leukemia (AML-M0) whose cells had a t(2;11)(p21;q23). Fluorescence in situ hybridization analysis with a probe for MLL showed that it was split, hybridizing to both the derivative 2 and 11 chromosomes. Nineteen other patients with 2p;11q translocations h